article-journal

The dynamic clustering of insulin receptor underlies its signaling and is disrupted in insulin resistance.
Insulin receptor (IR) signaling is central to normal metabolic control and is dysregulated in metabolic diseases such as type 2 …
Alessandra Dall'Agnese, Jesse M Platt, Ming M Zheng, Max Friesen, Giuseppe Dall'Agnese, Alyssa M Blaise, Jessica B Spinelli, Jonathan E Henninger, Erin N Tevonian, Nancy M Hannett, Charalampos Lazaris, Hannah K Drescher, Lea M Bartsch, Henry R Kilgore, Rudolf Jaenisch, Linda G Griffith, Ibrahim I Cisse, Jacob F Jeppesen, Tong I Lee, Richard A Young
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Shifting gears: Study of immune system parameters of male habitual marathon runners.
AIM: Marathon is a running event in which athletes must cover a distance of 42.195 km. In addition to participating in marathons, …
Ioannis Panagoulias, Nikolaos Charokopos, Iason Thomas, Panagiota I Spantidea, Anne-Lise de Lastic, Maria Rodi, Spyridoula Anastasopoulou, Ioanna Aggeletopoulou, Charalampos Lazaris, Kiriakos Karkoulias, Lydia Leonidou, Neoklis A Georgopoulos, Kostas B Markou, Athanasia Mouzaki
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Tumor immune infiltration estimated from gene expression profiles predicts colorectal cancer relapse.
A substantial fraction of patients with stage I-III colorectal adenocarcinoma (CRC) experience disease relapse after surgery with …
Yasmin Kamal, Dennis Dwan, Hannah J Hoehn, Rebeca Sanz-Pamplona, M Henar Alonso, Victor Moreno, Chao Cheng, Michael J Schell, Youngchul Kim, Seth I Felder, Hedy S Rennert, Marilena Melas, Charalampos Lazaris, Joseph D Bonner, Erin M Siegel, David Shibata, Gad Rennert, Stephen B Gruber, H Robert Frost, Christopher I Amos, Stephanie L Schmit
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RNA-Mediated Feedback Control of Transcriptional Condensates.
Regulation of biological processes typically incorporates mechanisms that initiate and terminate the process and, where understood, …
Jonathan E Henninger, Ozgur Oksuz, Krishna Shrinivas, Ido Sagi, Gary LeRoy, Ming M Zheng, J Owen Andrews, Alicia V Zamudio, Charalampos Lazaris, Nancy M Hannett, Tong Ihn Lee, Phillip A Sharp, Ibrahim I Cisse, Arup K Chakraborty, Richard A Young
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RNA-Mediated Feedback Control of Transcriptional Condensates.
Extent and context dependence of pleiotropy revealed by high-throughput single-cell phenotyping.
Pleiotropy-when a single mutation affects multiple traits-is a controversial topic with far-reaching implications. Pleiotropy plays a …
Kerry A Geiler-Samerotte, Shuang Li, Charalampos Lazaris, Austin Taylor, Naomi Ziv, Chelsea Ramjeawan, Annalise B Paaby, Mark L Siegal
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Three-dimensional chromatin landscapes in T cell acute lymphoblastic leukemia.
Differences in three-dimensional (3D) chromatin architecture can influence the integrity of topologically associating domains (TADs) …
Andreas Kloetgen, Palaniraja Thandapani, Panagiotis Ntziachristos, Yohana Ghebrechristos, Sofia Nomikou, Charalampos Lazaris, Xufeng Chen, Hai Hu, Sofia Bakogianni, Jingjing Wang, Yi Fu, Francesco Boccalatte, Hua Zhong, Elisabeth Paietta, Thomas Trimarchi, Yixing Zhu, Pieter Van Vlierberghe, Giorgio G Inghirami, Timothee Lionnet, Iannis Aifantis, Aristotelis Tsirigos
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On epigenetic plasticity and genome topology.
Mounting evidence links genetic lesions with genome topology alterations and aberrant gene activation. However, the role of epigenetic …
Charalampos Lazaris, Iannis Aifantis, Aristotelis Tsirigos
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Oncogenic hijacking of the stress response machinery in T cell acute lymphoblastic leukemia.
Cellular transformation is accompanied by extensive rewiring of many biological processes leading to augmented levels of distinct types …
Nikos Kourtis, Charalampos Lazaris, Kathryn Hockemeyer, Juan Carlos Balandrán, Alejandra R Jimenez, Jasper Mullenders, Yixiao Gong, Thomas Trimarchi, Kamala Bhatt, Hai Hu, Liza Shrestha, Alberto Ambesi-Impiombato, Michelle Kelliher, Elisabeth Paietta, Gabriela Chiosis, Monica L Guzman, Adolfo A Ferrando, Aristotelis Tsirigos, Iannis Aifantis
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Oncogenic hijacking of the stress response machinery in T cell acute lymphoblastic leukemia.
Role of Dysregulated Cytokine Signaling and Bacterial Triggers in the Pathogenesis of Cutaneous T-Cell Lymphoma.
Cutaneous T-cell lymphoma is a heterogeneous group of lymphomas characterized by the accumulation of malignant T cells in the skin. The …
Melania H Fanok, Amy Sun, Laura K Fogli, Vijay Narendran, Miriam Eckstein, Kasthuri Kannan, Igor Dolgalev, Charalampos Lazaris, Adriana Heguy, Mary E Laird, Mark S Sundrud, Cynthia Liu, Jeff Kutok, Rodrigo S Lacruz, Jo-Ann Latkowski, Iannis Aifantis, Niels Ødum, Kenneth B Hymes, Swati Goel, Sergei B Koralov
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Stratification of TAD boundaries reveals preferential insulation of super-enhancers by strong boundaries.
The metazoan genome is compartmentalized in areas of highly interacting chromatin known as topologically associating domains (TADs). …
Yixiao Gong, Charalampos Lazaris, Theodore Sakellaropoulos, Aurelie Lozano, Prabhanjan Kambadur, Panagiotis Ntziachristos, Iannis Aifantis, Aristotelis Tsirigos
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